| Description | Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities, inhibits selective Toll-like receptors, inhibits free fatty acids It inhibits selective Toll-like receptors, inhibits free fatty acid palmitate-induced chondrocyte inflammation and attenuates post-traumatic arthritis in obese mice, and inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes, which can be used for validation and mammary carcinoma studies. |
| In vitro | 在 SH-SY5Y、IMR-32、NGP、SKNF-1和 SK-N-BE(2) 细胞中，Sparstolonin B（1 µM、5 µM、10 µM 或 20 µM；2-4天）能在治疗 2 天（ SH-SY5Y 和 IMR-32 细胞）、3天（NGP细胞）或 4 天（SKNF-1和SK-N-BE(2)细胞）后，显著且剂量依赖性地抑制所有神经母细胞瘤细胞系的存活率[3]。 |
| In vivo | 在 5-6 周龄的雄性 C57Bl/6 小鼠（体重 18-20 克）中，Sparstolonin B（100 μg/只小鼠；腹腔注射）显著降低了 LPS 诱导脓毒症小鼠模型中的 TNFα和 IL-1β 表达水平[1]。 |
| molecular weight | 268.22 |
| Molecular formula | C15H8O5 |
| CAS | 1259330-61-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/mL (18.64 mM), Sonication is recommended. |
| References | 1. Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479. 2. Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25. 3. Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96. |