| Description | Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2. |
| In vivo | 在研究的动物中，Spantide acetate（50 nM和100 nM）均导致呼吸完全停止[1]。在雌性C57BL/6和BALB/c小鼠中，Spantide acetate（36 μg；i.p.）显著降低细菌计数、穿孔性角膜以及PMNs的数量。Spantide acetate降调了I型细胞因子IFN-γ、IL-6、TNF-α、MIP-2和IL-1β的mRNA水平[2]。 |
| Synonyms | Spantide acetate(91224-37-2 Free base) |
| molecular weight | 1557.84 |
| Molecular formula | C77H112N20O15 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 15.58 mg/mL (10 mM) |
| References | 1. M Zubrzycka, et al. Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr Regul. 2000 Mar;34(1):13-8. 2. Linda D Hazlett, et al. Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):797-807. 3. J C Beaujouan, et al. Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br J Pharmacol. 1993 Mar;108(3):793-800. |