| Description | Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects. |
| Target activity | Na+, K+-ATPase:40 nM |
| Synonyms | Sodium vanadate, 钒酸钠, Trisodium vanadate, Sodium pervanadate |
| molecular weight | 183.9 |
| Molecular formula | Na3O4V |
| CAS | 13721-39-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 8.33 mg/mL (45.29 mM), Sonication is recommended. |
| References | 1. Wu Y, et al. Acta Pharmacol Sin, 2005, 26(3), 345-352. 2. Cantley LC Jr, et al. J Biol Chem, 1977, 252(21), 7421-7423. 3. Kawano T, et al. J Cereb Blood Flow Metab, 2001, 21(11), 1268-1280. 4. Wu DN, et al. Neurosci Lett, 2006, 404(1-2), 98-102. 5. Fukunaga K, et al. J Pharmacol Sci, 2005, 98(3), 205-211. 6. Jiang T Y, Pan Y F, Wan Z H, et al. PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma[J]. Science Translational Medicine. 2020, 12(562). |
| Citations | 1. Jiang T Y, Pan Y F, Wan Z H, et al. PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma. Science Translational Medicine. 2020, 12(562). |