| Description | Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator. |
| In vitro | Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines[1]. |
| Synonyms | Oleic acid sodium salt, Sodium oleate, cis-9-Octadecenoic acid sodium salt |
| molecular weight | 304.44 |
| Molecular formula | C18H33NaO2 |
| CAS | 143-19-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL Ethanol: 1.5 mg/mL H2O: 20 mg/mL (65.69 mM), Sonication is recommended. DMSO: Insoluble |
| References | 1. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330. 2. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8. |