| Description | Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. |
| In vitro | Sodium citrate（12.5 mM；72小时）以剂量依赖的方式诱导细胞凋亡以及在G2/M和S阶段的细胞周期阻滞。Citric acid trisodium（12.5 mM；48小时）提高了FAS、BAX、BID、AIF、EndoG、细胞色素c、PARP、GADD153、GRP78及caspase-3、-8、-9的表达，同时降低了BCL-2和BCL-Xl的表达[1]。 |
| In vivo | Sodium citrate 是柠檬酸的钠盐，具有碱化作用。吸收后，柠檬酸钠分解为钠离子和柠檬酸离子；有机柠檬酸离子被代谢成碳酸氢盐离子，导致血浆碳酸氢盐浓度增加，缓冲过量氢离子，提高血液pH值，潜在地逆转酸中毒。此外，由于Sodium citrate 的给药增加了自由钠负荷，可能增加血管内血量，促进碳酸氢盐化合物的排泄和具有抗尿石效应[2]。 |
| Synonyms | Citrosodine, Natrocitral, 柠檬酸钠 |
| molecular weight | 258.07 |
| Molecular formula | C6H5Na3O7 |
| CAS | 68-04-2 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. 2. Li K, Xu Y. Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis. Int J Clin Exp Med. 2015 Apr 15;8(4):6578-84. 3. Chen X, et al. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. |