| Description | SMER18, a small molecule enhancer of rapamycin, acts as an mTOR-independent inducer of autophagy and can be used to study neurodegenerative diseases. |
| In vitro | SMER18 是一种雷帕霉素的小分子增强剂，能够作为 mTOR 非依赖性的自噬诱导剂发挥作用，可以增强增强诸如突变型 htt（与亨廷顿病相关）和 A53T α-突触核蛋白（与家族性帕金森病相关）等自噬底物的清除[1]。 |
| Synonyms | SMER-18, SMER 18 |
| molecular weight | 287.74 |
| Molecular formula | C16H14ClNO2 |
| CAS | 944153-47-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (278.03 mM), Sonication is recommended. |
| References | 1. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338. |