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SMAPP1

CAS No.: 327081-00-5

SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 p
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Description SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.
molecular weight 563.65
Molecular formula C27H25N5O5S2
CAS 327081-00-5
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Sci Pharm. 2015 Jun 22;83(3):535-48. doi: 10.3797/scipharm.1502-01. Print 2015 Jul-Sep. PubMed PMID: 26839837; PubMed Central PMCID: PMC4727795. 2. Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4. PubMed PMID: 26178009; PubMed Central PMCID: PMC4504130. 3. Pereira RV, Gomes Mde S, Olmo RP, Souza DM, Jannotti-Passos LK, Baba EH, Castro-Borges W, Guerra-Sá R. NEDD8 conjugation in Schistosoma mansoni: genome analysis and expression profiles. Parasitol Int. 2013 Apr;62(2):199-207. doi: 10.1016/j.parint.2012.12.009. Epub 2013 Jan 8. PubMed PMID: 23313772.