| Description | SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM.SLC26A3 is a solute carrier (SLC) protein and a member of the SLC26 family, which has a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate.SLC26A3 is downregulated in adenomas (DRA) and is involved in the intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea. SLC26A3 is downregulated in adenomas (DRA), is involved in the intestinal absorption of chloride and oxalate, and is associated with chloride-losing diarrhea. |
| In vitro | SLC26A3-IN-1（10 μM；10分钟）对SLC26A3的抑制率为87%。[1] |
| Target activity | SLC26A3:340 Nm |
| molecular weight | 358.39 |
| Molecular formula | C23H18O4 |
| CAS | 307552-53-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (139.51 mM), Sonication is recommended. |
| References | 1. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023;249:115149. |