PeptideDB

SKI 5C

CAS No.: 120005-55-2

SKI 5C is a selective inhibitor of Sphingosine Kinase 1.
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Description SKI 5C is a selective inhibitor of Sphingosine Kinase 1.
Synonyms SKI5C, SKI-5C
molecular weight 435.64
Molecular formula C26H45NO4
CAS 120005-55-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Li ZH, Tao YF, Xu LX, Zhao H, Li XL, Fang F, Wu Y, Lu J, Li YH, Du WW, Ren JL, Li YP, Xu YY, Feng X, Wang J, He WQ, Pan J. A novel sphingosine kinase 1 inhibitor (SKI-5C) induces cell death of Wilms' tumor cells in vitro and in vivo. Am J Transl Res. 2016 Nov 15;8(11):4548-4563. eCollection 2016. PubMed PMID: 27904661; PubMed Central PMCID: PMC5126303. 2. Tian T, Tian W, Yang F, Zhao R, Huang Q, Zhao Y. Sphingosine kinase 1 inhibition improves lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting mitogen-activated protein kinases pathway. United European Gastroenterol J. 2016 Oct;4(5):677-685. Epub 2016 Mar 2. PubMed PMID: 27733910; PubMed Central PMCID: PMC5042311. 3. Datta A, Loo SY, Huang B, Wong L, Tan SS, Tan TZ, Lee SC, Thiery JP, Lim YC, Yong WP, Lam Y, Kumar AP, Yap CT. SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. Oncotarget. 2014 Aug 15;5(15):5920-33. PubMed PMID: 25153718; PubMed Central PMCID: PMC4171602.