| Description | SJPYT-195 is a cytotoxic agent targeting GSPT1 for degradation, suitable for PROTAC (PROteolysis TArgeting Chimera) synthesis [1]. |
| In vitro | SJPYT-195 (24小时) 在结直肠癌细胞株SNU-C4中（SNU-C4 3xFLAG-PXR KI细胞）强效且高效率地降低内源性PXR（孕烷X受体）蛋白，其半最大降解浓度（DC 50 ）为310 ± 130 nM，最大降解效能（D Max ）达到85 ± 1% [1]。SJPYT-195通过降解GSPT1来减少PXR蛋白的表达[1]。 |
| molecular weight | 666.68 |
| Molecular formula | C35H34N6O8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |