| Description | SJ572403 is an inhibitor of disordered protein p27 with Kd of 2.2 mM for specific regions within the D2 subdomain of p27-KID. SJ572403 can be used in studies about diseases with intrinsically disordered proteins. |
| In vitro | SJ572403（10 μM-3 mM）能够替代Cdk2/cyclin A上的p27-D2，并部分恢复Cdk2的激酶活性。SJ572403（0-3 mM）调节Cdk对p27[1]的调控。 |
| Synonyms | SJ403 |
| molecular weight | 275.31 |
| Molecular formula | C13H17N5O2 |
| CAS | 19970-45-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12.5 mg/mL (45.4 mM), Sonication is recommended. |
| References | 1. Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1). Sci Rep. 2015 Oct 28;5:15686. |