| Description | SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation and attenuating pro-inflammatory cytokine release. It demonstrates renal protective effects and is active in vivo, showing efficacy in AKI mouse models subjected to lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury [1]. |
| molecular weight | 582.12 |
| Molecular formula | C28H32ClN7O3S |
| CAS | 2951090-00-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |