| Description | SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively). |
| In vitro | SIRT-IN-2是一种高效的缩短全谱SIRT1/2/3抑制剂，其IC50值分别为4、4、7 μM。SIRT-IN-2在催化活性位点内相同位置结合（RMS=0.29 Å），占据了烟酰胺C-口袋和乙酰赖氨酸底物通道。 |
| Target activity | SIRT1:4 nM, SIRT3:7 nM, SIRT2:1 nM |
| molecular weight | 383.49 |
| Molecular formula | C15H21N5O3S2 |
| CAS | 1431411-66-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 62.5 mg/mL (151.24 mM), Sonication is recommended. |
| References | 1. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. |