| Description | Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensatory cirrhosis caused by non-alcoholic steatohepatitis. |
| Synonyms | GS 6624, AB 0024 |
| molecular weight | N/A |
| CAS | 1318075-13-6 |
| Storage | store at low temperature | store at -80°C |
| References | 1. Wei Chen, et al. Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis. Hepatology. 2020 Aug;72(2):729-741. |