| Description | SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases the anti-inflammatory cytokine IL-10 and decreases the pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1]. |
| molecular weight | 507.58 |
| Molecular formula | C27H31F2N7O |
| CAS | 2927557-06-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |