| Description | Shz 1 is a cardiogenic agent that induces phenotypic differentiation and various cardiac-specific genes including sarcomeric tropomyosin. |
| In vitro | Shz-1在心脏转录中对Nkx2.5基因显示出约1.5倍的增加。Shz-1增强了肌原纤维TPM1（包括TPM1α和TPM1κ）和肌原纤维TPM4α转录表达。Shz-1激活了C2C12细胞中蝾螈TPM4启动子驱动的异位表达[1]。 |
| molecular weight | 355.21 |
| Molecular formula | C13H11BrN2O3S |
| CAS | 326886-05-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4.8 mg/mL (13.51 mM) |
| References | 1. Changlong Nan, et al. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule. Cardiovasc Toxicol. 2015 Jan;15(1):29-40. |