| Description | SHP2-IN-14 (compound 27) is a potent, orally active allosteric inhibitor of SHP2, displaying strong anti-tumor activity with an IC50 of 7 nM. It inhibits tumor progression in NCI-H358 tumor-bearing mice and demonstrates favorable pharmacokinetic properties and safety [1]. |
| molecular weight | 483.35 |
| Molecular formula | C22H20Cl2N8O |
| CAS | 2673400-91-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |