| Description | SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. |
| molecular weight | 435.29 |
| Molecular formula | C17H12Cl2N6O2S |
| CAS | 1426214-51-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |