| Description | SGK1-IN-1 is a highly active and selective SGK-1 inhibitor(IC50 of 1 nM). |
| In vitro | SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3(IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively). SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2]. |
| Target activity | SGK1:1 nM |
| molecular weight | 418.83 |
| Molecular formula | C17H12ClFN6O2S |
| CAS | 1279829-87-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. ARYL SULFONOHYDRAZIDES. WO 2013041119 A1. 2. Halland N, et al. Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8. |