| Description | SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult. |
| molecular weight | 388.63 |
| Molecular formula | C26H44O2 |
| CAS | 35882-85-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S. Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. Br J Pharmacol. 2015 Mar;172(5):1333-47. doi: 10.1111/bph.13007. Epub 2015 Jan 13. PubMed PMID: 25377730; PubMed Central PMCID: PMC4337705. 2. Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300. doi: 10.1523/JNEUROSCI.2619-13.2013. PubMed PMID: 24174662; PubMed Central PMCID: PMC3812502. |