| Description | SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist with IC50 of 199 nM. Antidepressant-like activity |
| Target activity | NPYY2 receptor:199 nM (IC50) |
| molecular weight | 446.6 |
| Molecular formula | C27H30N2O2S |
| CAS | 443292-81-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 22.33 mg/mL DMSO: 40 mg/mL (89.57 mM), Sonication is recommended. |
| References | 1. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463. 2. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57. |