| Description | Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 µM. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis. |
| Target activity | Separase:14.8 µM |
| Synonyms | Sepin 1, Sepin1, 2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide |
| molecular weight | 223.19 |
| Molecular formula | C9H9N3O4 |
| CAS | 163126-81-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Slightly soluble |
| References | 1. Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4446-50. 2. Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC, Pati D. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul;19(6):878-89. |