| Description | Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex. |
| In vitro | Scyliorhinin II acetate对NK1和NK2受体的影响较小。对于NK1/NK3和NK2/NK3，其Ki值分别为176和200[2]。 |
| In vivo | 在小鼠体内，Scyliorhinin II acetate (i.c.v.) 引发了剂量相关的强烈双后肢抓挠反应，具有相当的有效性（ED50 = 0.08 nmol）[1]。 |
| Target activity | NK3:2.5 nM(Ki) |
| molecular weight | 1911.14 |
| Molecular formula | C79H123N21O28S3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91. 2. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. |