| Description | SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. |
| In vivo | SBI-477 同时抑制了三酰甘油（TAG）合成，并增强了人类骨骼肌细胞的基础葡萄糖摄取。SBI-477 通过抑制转录因子 MondoA 活性，刺激胰岛素信号传导，导致胰岛素通路抑制剂硫氧还蛋白互作蛋白（TXNIP）和含阿莱斯廷结构域4（ARRDC4）表达降低。在肌细胞中耗尽 MondoA 复制了 SBI-477 对葡萄糖摄取和肌细胞脂质积累的影响。 |
| molecular weight | 483.54 |
| Molecular formula | C24H25N3O6S |
| CAS | 781628-99-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (93.06 mM), Sonication is recommended. |
| References | 1. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79. |