| Description | SBE-β-CD (Sulfobutylether-β-Cyclodextrin) is a β-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether. SBE-β-CD is widely used as a co-solvent in biological experiments. |
| In vivo | 方法：为研究体内活性，将 MR-L2 (300 nl; 2 × 10–4 M; 1:20, DMSO in 20% SBE-β-CD) 微量输注到大鼠 NAcs 中。结果：MR-L2 显著减少了无活性按压，而对照组给予 SBE-β-CD 没有效果。[1] |
| Synonyms | 磺丁基-Β-环糊精, Sulfobutylether-β-Cyclodextrin |
| molecular weight | N/A |
| CAS | 182410-00-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 250 mg/mL, Sonication is recommended. DMSO: 5.625 mg/mL, Sonication and heating are recommended. |
| References | 1. Sharp BM, et al. Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine. Sci Rep. 2024 Jan 31;14(1):2562. 2. Lockwood SF, et al. Improved aqueous solubility of crystalline astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) by Captisol (sulfobutyl ether beta-cyclodextrin). J Pharm Sci. 2003 Apr;92(4):922-926. 3. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67 4. Fettiplace MR, et al. Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. Acad Emerg Med. 2015 May;22(5):508-17 |
| Citations | 1. Sharp B M, Jiang Q, Kim P, et al.Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 modulates the motivation to chronically self-administer nicotine.bioRxiv.2023: 2023.03. 07.531588. 2. Sharp B M, Jiang Q, Kim P, et al.Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific Reports.2024, 14(1): 2562. |