| Description | SB-217452 is a potent seryl tRNA synthetase inhibitor isolated from Streptomyces. |
| Synonyms | SB217452 |
| molecular weight | 476.46 |
| Molecular formula | C16H24N6O9S |
| CAS | 93301-58-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17;409(4):814-9. doi: 10.1016/j.bbrc.2011.05.096. Epub 2011 May 23. PubMed PMID: 21624347; PubMed Central PMCID: PMC3124823. 2. Zeng Y, Roy H, Patil PB, Ibba M, Chen S. Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother. 2009 Nov;53(11):4619-27. doi: 10.1128/AAC.00782-09. Epub 2009 Aug 31. PubMed PMID: 19721072; PubMed Central PMCID: PMC2772349. 3. Stefanska AL, Fulston M, Houge-Frydrych CS, Jones JJ, Warr SR. A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species. J Antibiot (Tokyo). 2000 Dec;53(12):1346-53. PubMed PMID: 11217799. |