| Description | Sardomozide dihydrochloride (CGP 48664 dihydrochloride) is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC, IC50 = 5 nM). |
| In vitro | In CHO/664 cells treated with DENSPM, Sardomozide inhibits cell growth without vacuole formation[1]. Sardomozide (3 μM) reduces intracellular SAMDC activity to 10%[2]. |
| Synonyms | CGP 48664 dihydrochloride, Sardomozide dihydrochloride |
| molecular weight | 303.19 |
| Molecular formula | C11H16Cl2N6 |
| CAS | 138794-73-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 10 mg/mL (32.98 mM), Sonication is recommended. DMSO: 3.33 mg/mL (10.99 mM), Sonication is recommended. |
| References | 1. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90. 2. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. |