| Description | Santin (5,7-Dihydroxy-3,6,4'-trimethoxyflavone) is a flavonoid extracted from birch buds exerting antiproliferative, anti-influenza activity and anti-cancer activity. Santin can be used in studies about anti-IAV drugs. |
| In vitro | Santin 显著降低胃癌（AGS）、结肠癌（DLD-1）和肝癌（HepG2）细胞的存活率、增殖能力和克隆形成能力。Santin 诱导细胞凋亡，并伴随 caspase-3、caspase-7、caspase-8 和 caspase-9的激活[1]。Santin 还在 MDCK 和 THP-1 细胞中显示出抗流感活性[2]。 |
| Synonyms | 5,7-Dihydroxy-3,6,4'-trimethoxyflavone |
| molecular weight | 344.32 |
| Molecular formula | C18H16O7 |
| CAS | 27782-63-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Szoka L, et al. Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells. J Cell Mol Med. 2021 Dec;25(24):11085-11096. 2. Zhong M, et al. Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways. J Asian Nat Prod Res. 2019 Dec;21(12):1205-1214. |