| Description | Samandarine is the main steroidal alkaloid secreted by the fire salamander (Salamandra salamandra). The compound is extremely toxic and causes convulsions, respiratory paralysis, and eventual death. |
| molecular weight | 305.45 |
| Molecular formula | C19H31NO2 |
| CAS | 467-51-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Oka K, Hara S. Stereoselective synthesis of samandarine nucleus. Tetrahedron Lett. 1969 May;(24):1987-90. PubMed PMID: 5790176. 2. Franke H, Partch R. The chemistry of samandarine model compounds. J Med Chem. 1966 Jul;9(4):643-4. PubMed PMID: 5968049. 3. Vences M, Sanchez E, Hauswaldt JS, Eikelmann D, Rodríguez A, Carranza S, Donaire D, Gehara M, Helfer V, Lötters S, Werner P, Schulz S, Steinfartz S. Nuclear and mitochondrial multilocus phylogeny and survey of alkaloid content in true salamanders of the genus Salamandra (Salamandridae). Mol Phylogenet Evol. 2014 Apr;73:208-16. doi: 10.1016/j.ympev.2013.12.009. Epub 2014 Jan 8. PubMed PMID: 24412216. 4. Mebs D, Pogoda W. Variability of alkaloids in the skin secretion of the European fire salamander (Salamandra salamadra terrestris). Toxicon. 2005 Apr;45(5):603-6. PubMed PMID: 15777956. |