| Description | SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM. It inactivates NDM-1 by oxidizing the enzyme's Zn(II)-thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1]. |
| In vitro | SA09-Cu（5-160 μg/mL；24小时）在40 μg/mL浓度下，能维持Vero E6与L929小鼠细胞的存活率在60%以上[1]。SA09-Cu（2, 4, 8, 16 μg/mL；24小时）对E. coli-BL21-NDM-1与EC23活细胞中NDM-1的活性显示出显著的剂量依赖抑制效果[1]。SA09-Cu自身的抗菌活性微弱，或几乎不具备（MIC≥64 μg/mL）[1]。 |
| molecular weight | 364.03 |
| Molecular formula | C8H16CuN2O2S4 |
| CAS | 155641-16-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |