| Description | (S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells. |
| In vitro | (S)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1]. |
| Synonyms | (S)-(-)-Verapamil hydrochloride |
| molecular weight | 491.06 |
| Molecular formula | C27H39ClN2O4 |
| CAS | 36622-28-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. 2. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309. |