| Description | S-Nitroso-N-acetylcysteine inhibits proliferation and survival of multiple MM cells. It acts by the S-nitrosylation-dependent inhibition of STAT3 and NF-κB. |
| Synonyms | S-Nitrosoacetylcysteine |
| molecular weight | 192.19 |
| Molecular formula | C5H8N2O4S |
| CAS | 56577-02-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bouressam ML, Meyer B, Boudier A, Clarot I, Leroy P, Genoni A, Ruiz-Lopez M, Giummelly P, Liminana P, Salgues V, Kouach M, Perrin-Sarrado C, Lartaud I, Dupuis F. In vivo and in silico evaluation of a new nitric oxide donor, S,S'-dinitrosobucillamine. Nitric Oxide. 2017 Dec 1;71:32-43. doi: 10.1016/j.niox.2017.10.004. Epub 2017 Oct 16. PubMed PMID: 29051112. 2. Kim J, Choi S, Saxena N, Singh AK, Singh I, Won JS. Regulation of STAT3 and NF-κB activations by S-nitrosylation in multiple myeloma. Free Radic Biol Med. 2017 May;106:245-253. doi: 10.1016/j.freeradbiomed.2017.02.039. Epub 2017 Feb 21. PubMed PMID: 28232202; PubMed Central PMCID: PMC5826580. 3. Meyer B, Genoni A, Boudier A, Leroy P, Ruiz-Lopez MF. Structure and Stability Studies of Pharmacologically Relevant S-Nitrosothiols: A Theoretical Approach. J Phys Chem A. 2016 Jun 23;120(24):4191-200. doi: 10.1021/acs.jpca.6b02230. Epub 2016 Jun 9. PubMed PMID: 27249061. 4. de Souza GF, de Oliveira MG. Intratablet S-nitrosation: A New Approach for the Oral Administration of S-nitrosothiols as Nitric Oxide Donors. J Pharm Sci. 2016 Jan;105(1):359-61. doi: 10.1016/j.xphs.2015.10.011. Epub 2015 Dec 18. PubMed PMID: 26852866. |