| Description | (S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders. |
| In vivo | 在进行 Morris 水迷宫学习的雄性 Lister-Hooded 大鼠中，(S)-MCPG（20 μg；脑室内注射；4天）削弱了大鼠在 Morris 水迷宫空间版本中的表现，但 1/10 的剂量则没有影响[2]。 |
| Synonyms | (+)-MCPG |
| molecular weight | 209.20 |
| Molecular formula | C10H11NO4 |
| CAS | 150145-89-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/mL (23.90 mM), Sonication is recommended. H2O: 80 mg/mL (382.41 mM), Sonication and adjust pH to 13 with 1M OH |
| References | 1. Bernadett Boda, et al. Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome. Eur J Neurosci. 2014 Apr;39(7):1130-7. 2. F Bordi, et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65. 3. Garrido-García A, de Andrés R, Jiménez-Pompa A, Soriano P, Sanz-Fuentes D, Martínez-Blanco E, Díez-Guerra FJ. Neurogranin Expression Is Regulated by Synaptic Activity and Promotes Synaptogenesis in Cultured Hippocampal Neurons. Mol Neurobiol. 2019 Nov;56(11):7321-7337. |