| Description | (S)-Baclofen has effects on excitation in the ascending auditory pathway leading to it a potential reagent for the treatment of hyperactive auditory disorders such as hyperacusis and tinnitus. |
| Synonyms | (+)-Baclofen, (L)-Baclofen |
| molecular weight | 213.66 |
| Molecular formula | C10H12ClNO2 |
| CAS | 66514-99-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Zheng Y, McPherson K, Smith PF. Effects of early and late treatment with L-baclofen on the development and maintenance of tinnitus caused by acoustic trauma in rats. Neuroscience. 2014 Jan 31;258:410-21. doi: 10.1016/j.neuroscience.2013.11.032. Epub 2013 Nov 26. PubMed PMID: 24291770. 2. Zheng Y, Vagal S, McNamara E, Darlington CL, Smith PF. A dose-response analysis of the effects of L-baclofen on chronic tinnitus caused by acoustic trauma in rats. Neuropharmacology. 2012 Feb;62(2):940-6. doi: 10.1016/j.neuropharm.2011.09.027. Epub 2011 Oct 12. PubMed PMID: 22005094. 3. Fromm GH, Terrence CF. Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia. Neurology. 1987 Nov;37(11):1725-8. PubMed PMID: 3313099. 4. Olpe HR, Demiéville H, Baltzer V, Bencze WL, Koella WP, Wolf P, Haas HL. The biological activity of d- and l-baclofen (Lioresal). Eur J Pharmacol. 1978 Nov 1;52(1):133-6. PubMed PMID: 214308. |