| Description | (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a selective agonist of human metabotropic glutamate receptor 8a (mGluR8a). |
| In vitro | (S)-3,4-DCPG 在表达 mGlu8 的细胞中抑制了 forskolin 刺激的 cAMP 形成，EC50 值为 0.031 µM[1]。 |
| Target activity | mGluR8a (human):31 nM (EC50) |
| Synonyms | (S)-3,4-Dicarboxyphenylglycine |
| molecular weight | 239.18 |
| Molecular formula | C10H9NO6 |
| CAS | 201730-11-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Soluble |
| References | 1. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. |