PeptideDB

Rubradirin

CAS No.: 11031-38-2

Rubradirin is an antibiotic with a complex chemical structure that is active vs. methicillin resistant staphylococci. It
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Description Rubradirin is an antibiotic with a complex chemical structure that is active vs. methicillin resistant staphylococci. It is a selective enzymatic peptide initiation inhibitor.
molecular weight 998.904
Molecular formula C48H46N4O20
CAS 11031-38-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Boll B, Heide L. A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation. Chembiochem. 2013 Jan 2;14(1):43-4. doi: 10.1002/cbic.201200633. Epub 2012 Dec 6. PubMed PMID: 23225745. 2. Hoeksema H, Lewis C, Mizsak SA, Shiley JA, Wait DR, Whaley HA, Zurenko GE. The isolation and characterization of rubradirin B. J Antibiot (Tokyo). 1978 Oct;31(10):945-8. PubMed PMID: 711617. 3. Bannister B, Zapotocky BA. Protorubradirin, an antibiotic containing a C-nitroso-sugar fragment, is the true secondary metabolite produced by Streptomyces achromogenes var. rubradiris. Rubradirin, described earlier, is its photo-oxidation product. J Antibiot (Tokyo). 1992 Aug;45(8):1313-24. PubMed PMID: 1399853. 4. Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK. Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061. Arch Microbiol. 2008 May;189(5):463-73. Epub 2007 Dec 14. PubMed PMID: 18080113.