| Description | RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity. |
| In vivo | After IV administration,RU-SKI 43 hydrochloride has a t1/2 of 17 min in mouse plasma[1]. |
| Target activity | Hhat:850 nM |
| molecular weight | 423.01 |
| Molecular formula | C22H31ClN2O2S |
| CAS | 1782573-67-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 51 mg/mL (120.56 mM) H2O: 2.5 mg/mL (5.91 mM), Sonication is recommended. |
| References | 1. Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.Nat Chem Biol. 2013 Apr;9(4):247-9. 2. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575. |