| Description | rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. This compound is capable of partially disrupting the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, which is implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1]. |
| molecular weight | 344.38 |
| Molecular formula | C18H21FN4O2 |
| CAS | 1332175-56-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |