| Description | RTIL 13 is a highly effective inhibitor of dynamin GTPase, exhibiting an IC50 value of 2.3 μM for dynamin I GTPase. Furthermore, it selectively interacts with the pleckstrin homology lipid binding domain. This compound effectively suppresses both receptor-mediated and synaptic vesicle endocytosis, demonstrating IC50 values of 9.3 μM and 7.1 μM, respectively. |
| In vitro | RTIL 13 inhibits receptor-mediated and synaptic vesicle endocytosis, with IC 50 s of 9.3 μM and 7.1 μM, respectively[2]. |
| Target activity | Dynamin I GTPase:2.3 µM (IC50) |
| molecular weight | 571.685 |
| Molecular formula | C30H55BrN2O3 |
| CAS | 1009376-10-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhang J, et, al. From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry. 2008 Jan; 32(1): 1-180. 2. Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle. Tuesday, December 28, 2021. |