| Description | (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Butyryltimolol is a β-adrenergic blocker [2]. |
| In vitro | Butyryltimolol is a prodrug of Timolol. Butyryltimolol is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption [1]. |
| molecular weight | 386.51 |
| Molecular formula | C17H30N4O4S |
| CAS | 2320274-78-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (258.73 mM), Sonication is recommended. |
| References | 1. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. 2. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. |