| Description | RPR-106541, a GR agonist, is used potentially for the treatment of asthma. |
| Synonyms | RPR106541 |
| molecular weight | 456.59 |
| Molecular formula | C24H34F2O4S |
| CAS | 159001-35-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Miller GK, Valerio MG, Pino MV, Larson JL, Viau A, Hamelin N, Labbé R, Banks CM. Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation. Toxicol Pathol. 2000 Mar-Apr;28(2):226-36. PubMed PMID: 10805140. 2. Stevens JC, Domanski TL, Harlow GR, White RB, Orton E, Halpert JR. Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602. PubMed PMID: 10411567. 3. Underwood SL, Raeburn D, Lawrence C, Foster M, Webber S, Karlsson JA. RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4+ T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung. Br J Pharmacol. 1997 Oct;122(3):439-46. PubMed PMID: 9351499; PubMed Central PMCID: PMC1564957. |