| Description | Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart. |
| molecular weight | 446.15 |
| Molecular formula | C10H10BrN5NaO5PS |
| CAS | 925456-59-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 30 mg/mL DMSO: 25 mg/mL PBS (pH 7.2): 10 mg/mL Ethanol: 0.5 mg/mL |
Rp-8-bromo-Cyclic AMPS (sodium salt)
CAS No.: 925456-59-3
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution
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