| Description | RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ). |
| In vitro | RP 70676是一种强效的兔子动脉ACAT抑制剂，其IC50值为40nM，并已证明对来自多种组织和物种（包括人类）的ACAT均为有效的抑制剂。RP 70676的IC50值范围从仓鼠肝脏ACAT的21纳摩尔到以胆固醇喂养的兔子肠道酶的108nM，在人类肝脏组织中（IC50：44nM）。在小鼠巨噬细胞中，该化合物在整个细胞P388D中IC50为540 nM。 |
| In vivo | 在NZW兔中，RP 70676（10 mg/kg，口服）在血浆中化合物浓度达到预期水平。 |
| Target activity | ACAT (rat):25 nM , ACAT (rabbit):44 nM |
| molecular weight | 416.58 |
| Molecular formula | C25H28N4S |
| CAS | 136609-26-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 125 mg/mL (300.06 mM), Sonication is recommended. |
| References | 1. M.J. Ashton, et al. RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT). Bioorganic & Medicinal Chemistry Letters Volume 2, Issue 5, 1992, Pages 375-380. |