| Description | RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. |
| In vivo | RORγt反向激动剂14（8e）通过静脉注射1 mg/kg后，半衰期为11小时。口服4 mg/kg剂量给小鼠时，RORγt反向激动剂14（8e）的最大血药浓度时间（t max）为2小时，生物利用度（%F）为101 [1]。在5-20 mg/kg剂量范围内，RORγt反向激动剂14（8e）所引起的关节炎评分降低程度与市售TNF解体受体伊坦尼普的鼠类等效剂量相当 [1]。 |
| molecular weight | 678.61 |
| Molecular formula | C26H26F8N2O6S2 |
| CAS | 2672496-70-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |