| Description | RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM. It demonstrates anti-proliferative effects in the HPAF-II pancreatic cancer xenograft model, inhibits the RAS/MAPK and AKT/mTORC1 signaling pathways, and triggers caspase-dependent apoptosis in pancreatic cancer cells [1]. |
| molecular weight | 540.86 |
| Molecular formula | C35H60N2O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |