PeptideDB

ROCK-IN-D3

CAS No.: 1219727-16-8

ROCK-IN-D3 is an effective and selective inhibitor of ROCK.
Sales Email:peptidedb@qq.com

This product is for research use only, not for human use. We do not sell to patients.

Description ROCK-IN-D3 is an effective and selective inhibitor of ROCK.
Synonyms ROCK inhibitor D3, ROCK-inhibitor-D3
molecular weight 334.41
Molecular formula C20H22N4O
CAS 1219727-16-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Rasche L, Chavan SS, Stephens OW, Patel PH, Tytarenko R, Ashby C, Bauer M, Stein C, Deshpande S, Wardell C, Buzder T, Molnar G, Zangari M, van Rhee F, Thanendrarajan S, Schinke C, Epstein J, Davies FE, Walker BA, Meissner T, Barlogie B, Morgan GJ, Weinhold N. Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing. Nat Commun. 2017 Aug 16;8(1):268. doi: 10.1038/s41467-017-00296-y. PubMed PMID: 28814763; PubMed Central PMCID: PMC5559527. 2. Liu K, Sun Y, Liu D, Ye S. Inhibition of Wnt/β-catenin signaling by IWR1 induces expression of Foxd3 to promote mouse epiblast stem cell self-renewal. Biochem Biophys Res Commun. 2017 Aug 26;490(3):616-622. doi: 10.1016/j.bbrc.2017.06.086. Epub 2017 Jun 16. PubMed PMID: 28630002. 3. Chen Y, Huang W, Jiang W, Wu X, Ye B, Zhou X. HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway. Oxid Med Cell Longev. 2016;2016:4196572. doi: 10.1155/2016/4196572. Epub 2016 Aug 2. PubMed PMID: 27563375; PubMed Central PMCID: PMC4985576. 4. Paintlia AS, Paintlia MK, Hollis BW, Singh AK, Singh I. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep;181(3):993-1006. doi: 10.1016/j.ajpath.2012.05.028. Epub 2012 Jul 13. PubMed PMID: 22796435; PubMed Central PMCID: PMC3432427.