| Description | Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. |
| In vitro | Robinetin 抑制 Proteus vulgaris 中的 DNA 合成，以及 S. aureus 中的 RNA 合成[2]。Robinetin 表现出光诱导激发态分子内质子转移，导致 ‘双色’（在 ‘蓝紫色’ 和 ‘黄绿色’ 区域）的类黄酮荧光特征，这两种颜色的相对贡献强烈受到荧光团所处局部环境的调制[3]。Robinetin（0.1-10 μM; 1 小时）以剂量依赖性方式抑制 HIV 整合酶的切割和整合[4]。 |
| In vivo | 使用0.5、12.5或25微摩尔Robinetin预处理可在TPA处理6小时后显著增强表皮ODC的诱导。然而，使用50或100微摩尔Robinetin处理在TPA处理6小时后减弱了ODC的诱导作用[2]。在Salmonella typhimurium试验中测定了抗突变性，Robinetin对 2-aminoanthracene的突变性抑制率达87%[2]。 |
| Synonyms | 3,3',4',5',7-Pentahydroxyflavone, 洋槐黄素 |
| molecular weight | 302.24 |
| Molecular formula | C15H10O7 |
| CAS | 490-31-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (330.86 mM) |
| References | 1. Chaudhuri S, et al. Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation. J Photochem Photobiol B. 2010 Jan 21;98(1):12-9. 2. Birt DF, et al. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis. 1986 Jun;7(6):959-63. 3. Manrique-de-la-Cuba MF, et al. Theoretical study of the antioxidant capacity of the flavonoids present in the Annona muricata (Soursop) leaves. J Mol Model. 2019 Jun 25;25(7):200. 4. Cushnie TP, Lamb AJ. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005 Nov;26(5):343-56. |