| Description | RO5256390 is a trace amine-associated receptor 1 (TAAR1) agonist, a highly conserved G-protein-coupled receptor that blocks psychostimulant-induced hyperarousal, and may be used in the study of neurological disorders. |
| molecular weight | 218.29 |
| Molecular formula | C13H18N2O |
| CAS | 1043495-96-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (137.43 mM), Sonication is recommended. |
| References | 1. Revel FG, et al. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2013 May;18(5):543-56. 2. Ferragud A, et al. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470. |