| Description | RO5101576 is a potent antagonist of LTB4 receptor. |
| Synonyms | RO-5101576, RO 5101576 |
| molecular weight | 630.75 |
| Molecular formula | C36H38O8S |
| CAS | 1123155-95-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. doi: 10.1073/pnas.1103029108. Epub 2011 Apr 27. PubMed PMID: 21525407; PubMed Central PMCID: PMC3101002. 2. Hicks A, Goodnow R Jr, Cavallo G, et al, Renzetti LM. Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):33-43. doi: 10.1016/j.prostaglandins.2010.02.003. Epub 2010 Mar 7. PubMed PMID: 20214997. |