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Ro 22-9194

CAS No.: 106134-33-2

Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (=10 μM) caused a concentration-dependent decrease in the maxi
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Description Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (>=10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity and shortening of action potential duration in guinea-pig ventricular cells.
Synonyms Ro-22-9194
molecular weight 384.35
Molecular formula C19H27Cl2N3O
CAS 106134-33-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Hisatome I, Tanaka Y, Sasaki N, Hiroe K, Ahmmed GU, Tsuboi M, Manabe I, Suga T, Yamamoto Y, Ohtahara A, Kinugawa T, Ogino K, Igawa O, Yoshida A, Saito M, Sato R, Shigemasa C. Influence of extracellular H+ and Ca2+ on Ro 22-9194-induced block of sodium current in cardiac myocytes. Gen Pharmacol. 1997 Oct;29(4):557-60. PubMed PMID: 9352302. 2. Karasaki S, Sato R, Katori R. The blocking mechanism of sodium currents by a new class I antiarrhythmic drug, Ro 22-9194, in isolated guinea-pig ventricular myocytes. Gen Pharmacol. 1997 Sep;29(3):379-86. PubMed PMID: 9378244. 3. Hiroe K, Hisatome I, Tanaka Y, Ahmmed GU, Sasaki N, Shimoyama M, Tsuboi M, Inoue Y, Manabe I, Yamamoto Y, Ohtahata A, Kinugawa T, Ogino K, Igawa O, Yoshida A, Shigemasa C, Sato R. Tonic block of the Na+ current in single atrial and ventricular guinea-pig myocytes, by a new antiarrhythmic drug, Ro 22-9194. Fundam Clin Pharmacol. 1997;11(5):402-7. PubMed PMID: 9342593. 4. Murakami M, Kinukawa M, Kanazawa T, Maruyama K, Miyagi M, Miyata H, Ujiie A. Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83. PubMed PMID: 8930195.